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Insidious Cerebral Capillary Trauma from Motor Vehicle-Induced Vibration

The advent of the motor vehicle nearly one century ago has greatly altered modern life. While modern industry and technology continue to develop, it is easy to enjoy the benefits of these improvements rather than consider their consequences. Motor vehicles, the most commonly used form of transportation, are highly regarded for their convenience. However, motor vehicles produce whole body vibration (WBV). Though motor vehicles have been greatly improved in recent years, WBV does still exist and its potentially devastating aftermath must be understood. In 2011, there was an estimated 5,338,000 police-reported motor vehicle traffic crashes. According to a recent study by Charlie Klauer of the Virginia Tech Transportation Institute Center for Vulnerable Road User Safety, fatigue is the cause of 20 percent of all U.S. automobile crashes. Our study on motor vehicle-induced-whole body vibration (MVWBV) challenges the previous notion of driver fatigue [1,2]. These results suggest that “driver

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Neurotoxicity Associated with Cancer Treatment

Cancer is one of the prevalent medical problems among people especially in more developed and industrialized population. Now a day, it is considered as the third leading cause of death following cardiovascular problems and accidents. Moreover, the therapeutic approach to malignant tumors has been developed significantly compared with 70s and 80s. Many immunotherapies and targeted therapies have been developed and approved for both solid tumors and hematologic malignancies. Curable approach has been available for many deadly malignancies and multiple treatment lines have been proposed and validated based on the clinical trials in the majority of cancers. Innovative technologies such as nanotechnology have been proposed and developed to optimize the bioavailability of the therapeutic agents within the tumor. However, adverse events associated with these novel therapeutic approaches have been inevitable. Many of these adverse events present acutely during or shortly after the completion o

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Insidious Cerebral Capillary Trauma from Motor Vehicle-Induced Vibration

The advent of the motor vehicle nearly one century ago has greatly altered modern life. While modern industry and technology continue to develop, it is easy to enjoy the benefits of these improvements rather than consider their consequences. Motor vehicles, the most commonly used form of transportation, are highly regarded for their convenience. However, motor vehicles produce whole body vibration (WBV). Though motor vehicles have been greatly improved in recent years, WBV does still exist and its potentially devastating aftermath must be understood. In 2011, there was an estimated 5,338,000 police-reported motor vehicle traffic crashes. According to a recent study by Charlie Klauer of the Virginia Tech Transportation Institute Center for Vulnerable Road User Safety, fatigue is the cause of 20 percent of all U.S. automobile crashes. Our study on motor vehicle-induced-whole body vibration (MV- WBV) challenges the previous notion of driver fatigue [1,2]. These results suggest that “drive

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Neuropharmacological Evaluation of Methanolic Extract

http://edelweisspublications.com/edelweiss/article/Neuropharmacological-Evaluation-Methanolic-Extract-Mercurialis-Annua-ENOA-16-102.pdf Current therapeutic for the treatment of anxiety is associated with a wild variety of prominent side effects. The traditional use of plant extract to health care can indicate an important source of new pharmaceuticals. In Morocco traditional medicine, the use of Mercurialis annua is commonly recommended for relief of anxiety. Nevertheless, despite  its popular use there are no studies related to its possible neuropharmacological effect. Here, we investigated the possible anxiolytic effect of the extract of M.annua after acute treatment in mice.

Anxiety is considered a common emotional phenomenon in the human population, occurring in response to physiological and/or environmental factors . When anxiety becomes excessive, it may be considered as an anxiety disorder, and can critically decrease the quality of life inducing several psychosomatic diseases.

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The Ronnie Gardiner Method An Innovative Music-Based Intervention

A key issue in neurorehabilitation is to improve or restore physical and psychosocial abilities, aiming to maximize activity and participation . In recent years, an innovative rhythm-and-music-based rehabilitation program has successfully been implemented across Europe, as well as in several non-European countries. The Ronnie Gardiner Method (RGM) was created in the 1980s by the Swedish jazz musician Ronnie Gardiner. RGM is now widely used within different settings such as neurological rehabilitation for people with stroke, Parkinson’s disease (PD), and multiple sclerosis, as well as in patients with dementia and depression. It is also used in programs targeting healthy aging, ADHD, autism, and dyslexia, and in ordinary school environments. The combination of music and other augmented sensory information, as well as multi-tasking movement exercises, makes it a potentially powerful tool in rehabilitation. RGM is described as an exercise regimen that challenges motor and cognitive-relate

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The Evolution in The Treatment of Multiple Myeloma

Multiple myeloma is the second more frequently haematological cancer in the western world, after non-Hodgkin lymphoma, being about the 1-2 % of all the cancers cases and the 10-13% of hematologic diseases. The disease is caused by an uncontrolled clonal proliferation of plasma cells in the bone marrow that accumulate in different parts of the body, usually in the bone marrow, around some bones, and rarely in other tissues, forming tumor deposits, called plasmocytomas. This uncontrolled clonal proliferation of plasma cells produces the secretion of an abnormal monoclonal immunoglobulin (paraprotein or M-protein) and prevents the formation of the other antibodies produced by the normal plasma cells that are destroyed. The anormal secretion of paraproteins unbalance the osteoblastosis and osteoclastosis processes, leading to bone lesions that cause lytic bone deposits and the release of calcium from bones (hypercalcemia) that may produce renal failure. Regions affected by bone lesions are

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Making The Connection: Are We Forgetting To Communicate?

As a neurophysiologist, talking about my research in non-scientific environments, I face a sort of dualistic reaction: there is an innate curiosity and interest in my interlocutors, which is often followed by a general worry/disbelief about the technologies we are now able to use to manipulate, at least in rodents, the brain functions. Given all the efforts every single researcher puts into his studies, and considering that science is for the whole world, I started wondering... what if, in all these efforts, we are forgetting something?Life sciences, more than other fields, are closer to the everyday life: to think about the body physiology, the brain functions, the immune system function is more ‘human-sized’, more familiar, than debating about subatomic particles or galaxies. This sort of ‘proximity’, however, sometimes leads to the belief that everybody can be in charge to formulate his own theories, but science is not based on democracy, and the consequences of these are recapitula

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Neuropharmacological Evaluation of Methanolic Extract

Anxiety is considered a common emotional phenomenon in the human population, occurring in response to physiological and/or environmental factors. When anxiety becomes excessive, it may be considered as an anxiety disorder, and can critically decrease the quality of life inducing several psychosomatic diseases. Benzodiazepines are the major class of compounds used in anxiety and they have remained the most commonly prescribed treatment for anxiety . Benzodiazepines can lead to disturbing effects, such as amnesia, dependence liability, and sedation . Therefore, the development of other anxiolytic drugs without such adverse effects is important for the treatment of anxiety disorders. Several traditionally used plants exhibit pharmacological properties with great potential for therapeutic applications in the treatment of central nervous system disorders, such as anxiety disorders . In folk medicine, some species belonging to the family Euphorbiaceae, such as Mercurialis annua, is known to

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Music-Based Intervention for Neurological Rehabilitation

RGM is described as an exercise regimen that challenges motor and  cognitive - related abilities by  its multi - tasking nature, and is  conceptualized as a music - based intervention, i.e., an experimental  protocol that uses music in various forms  to aid therapeutic effects [2]. Because RGM is ‘a physical activity that is planned, structured, and repetitive,  aiming to increase or maintain physical fitness’ [3] , i t also  meets the criteria for an exercise intervention. The research on the  efficacy of RGM is still scarce, but a few scientific trials within the  field of neurorehabilitation have thus far shown prom ising results. A  Swedish randomized controlled study on stroke survivors found that  the intervention facilitated the participant’s own perception of  recovery, as well as long - lasting improvements concerning balance,  grip force, and working memory [4].  Individual interviews were also  undertaken with participants to explore personal experiences  (submitted manuscri

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Neurotoxicity Associated with Cancer Treatment

Cancer is one of the prevalent medical problems among people especially in more developed and industrialized population. Now a day, it is considered as the third leading cause of death following cardiovascular problems and accidents. Moreover, the therapeutic approach to malignant tumors has been developed significantly compared with 70s and 80s. Many immunotherapies and targeted therapies have been developed and approved for both solid tumors and hematologic malignancies. Curable approach has been available for many deadly malignancies and multiple treatment lines have been proposed and validated based on the clinical trials in the majority of cancers. Innovative technologies such as nanotechnology have been proposed and developed to optimize the bioavailability of the therapeutic agents within the tumor. However, adverse events associated with these novel therapeutic approaches have been inevitable. Many of these adverse events present acutely during or shortly after the completion o

continue reading →
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