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HIV AIDS

by Barbarawoods1 month ago

Human immunodeficiency virus disease and AIDS (HIV/AIDS) is a range of conditions caused by contamination with the human immunodeficiency virus (HIV). Following introductory disease, a man may not see any manifestations or may encounter a concise time of flu like ailment. Commonly, this is trailed by a drawn out period without any side effects. As the contamination advances, it meddles more with the safe framework, expanding the danger of creating basic diseases, for example, tuberculosis, and in addition other crafty contaminations, and tumors that once in a while influence individuals who have working insusceptible frameworks. These late manifestations of disease are alluded to as (AIDS). This stage is regularly additionally connected with unintended weight reduction.

HIV is spread essentially by unprotected sex (counting butt-centric and oral sex), sullied blood transfusions, hypodermic needles, and from mother to child amid pregnancy, conveyance, or breastfeeding. Some natural liq

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Chemical biology

by Barbarawoods2 months ago

Chemical biology is a logical order crossing the fields of chemistry and biology. The order includes the use of compound procedures, investigation, and frequently little particles delivered through engineered science, to the examination and control of organic frameworks. Rather than organic chemistry, which includes the investigation of the science of biomolecules and regulation of biochemical pathways inside and between cells, chemical biology deals with chemistry applied to biology. A few types of Chemical biology endeavor to answer organic inquiries by specifically testing living frameworks at the substance level. As opposed to inquire about utilizing natural chemistry, hereditary qualities, or atomic science, where mutagenesis can give another adaptation of the living being, cell, or biomolecule of intrigue, compound science tests frameworks in vitro and in vivo with little particles that have been intended for a particular reason or recognized based on biochemical or cell-based sc

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CRISPR CUREs: Running with Molecular Scissors in the Classroom

by Barbarawoods2 months ago

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) is a family of DNA sequences in prokaryotes. It is one of the defense mechanism in prokaryotes, these sequences contains snippets of DNA are formed due to infection of viruses in bacteria and are used by the prokaryote to detect and destroy DNA from similar viruses during subsequent attacks and form the basis of a technology known as CRISPR/Cas9 that effectively and specifically changes genes within organisms.

During a CURE, students use basic science practices to complete novel, relevant, collaborative research, which the student is required to present in some form at the end of the course. This creates a learning experience that does not only impart knowledge, but also teaches students important scientific skills like asking impactful questions, forming hypotheses, gathering and analyzing data, and drawing conclusions from their work.

Biochemistry Modern Applications welcome submissions related to above fields. Auth

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Neuro Effects of Opioids on the Human Brain

by Barbarawoods2 months ago

This paper is an examination of the neuro effects of opioids on the human brain. The research examines the brain receptors, region, enzymes, agonists involved, and the results of its interaction with opioids. Examination of the pharmacological effect on receptors located in the neural cell membranes shows that the most important aspect is the modulation of the K and Ca ions channels. This is mediated by the activation of the delta, kappa and mu opioid receptors in the peripheral and central nervous systems. The study found that opioid receptors are coupled by guanine nucleotide binding proteins (G-proteins) to the K+ channel and voltage sensitive Ca++ channel, particularly, the N-type channel. The channels are inhibited if K+ outwards release is increased leading to short polarization time. The outward movement occurs in several regions of the spinal cords, brain, and the myenteric plexus. The rapid K+ outward movement is associated with the observed hyperpolarization and inhibition ca

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The Prevalence and Incidence of Hepatitis C in the Anguillan Prison Population

by Barbarawoods2 months ago

Background:

The purpose of this project was to determine the prevalence of Hepatitis C among the inmates of Her Majesty’s Prison in Anguilla, British West Indies, as well as the rate of transmission whilst incarcerated. Participation was voluntarily by 24 participants and confidentiality was maintained by replacing the inmate’s names with numbers.

Methods:

A validated questionnaire was given and guided towards lifestyle, behaviors while incarcerated and knowledge of the disease and safety precautions. Following the survey, Hepatitis C testing was performed via an immunoassay for the presence of antibodies in the samples serum.

Findings:

There was one inmate who tested positive for Hepatitis C as a part of his initial work up upon incarceration, and the same inmate was found to be positive for HCV after our testing; concluding, there was no increase in the number of affected inmates.

Conclusion:

This research was beneficial in educating the inmates of Anguilla about hepatitis

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Neuro Effects of Opioids on the Human Brain

by Barbarawoods2 months ago

Previous researchers have explored the effect of opioids on the brain. Its adverse effects include respiratory depression, nausea, sedation, dysphoria, and impaired cognition. Opioids also modulate emotions, stress, rewards, emotions, memory, and learning (Feng et al., 2012). The euphoria and pain-relieving properties of opioids have been discussed since the Sumerian times. Research trace the mechanism of action of opioids to the coupling of receptors and inhibitors like the G-protein. The couple is activated by an agonist such an exogenous, or an endogenous μ-opioid peptide endorphin, the Gα, and Gβγ dissociate and act on effector pathways (van Rijn, DeFriel & Whistler, 2013). Pharmacological research found that pertussis-toxin-sensitive G proteins coupled with all the four types of opioids receptors. However, the most important aspect of the mode of action of the opioid receptor is its modulation of the K and Ca ions channels (Kaye et al., 2018). The effect of opioids is mediated by

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Neuro Effects of Opioids on the Human Brain

by Barbarawoods2 months ago

This paper is an examination of the neuro effects of opioids on the human brain. The research examines the brain receptors, region, enzymes, agonists involved, and the results of its interaction with opioids. Examination of the pharmacological effect on receptors located in the neural cell membranes shows that the most important aspect is the modulation of the K and Ca ions channels. This is mediated by the activation of the delta, kappa and mu opioid receptors in the peripheral and central nervous systems. The study found that opioid receptors are coupled by guanine nucleotide binding proteins (G-proteins) to the K+ channel and voltage sensitive Ca++ channel, particularly, the N-type channel. The channels are inhibited if K+ outwards release is increased leading to short polarization time. The outward movement occurs in several regions of the spinal cords, brain, and the myenteric plexus. The rapid K+ outward movement is associated with the observed hyperpolarization and inhibition c4

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