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The Prevalence and Incidence of Hepatitis C in the Anguillan Prison Population

by Barbarawoods23 hours ago

Background:

The purpose of this project was to determine the prevalence of Hepatitis C among the inmates of Her Majesty’s Prison in Anguilla, British West Indies, as well as the rate of transmission whilst incarcerated. Participation was voluntarily by 24 participants and confidentiality was maintained by replacing the inmate’s names with numbers.

Methods:

A validated questionnaire was given and guided towards lifestyle, behaviors while incarcerated and knowledge of the disease and safety precautions. Following the survey, Hepatitis C testing was performed via an immunoassay for the presence of antibodies in the samples serum.

Findings:

There was one inmate who tested positive for Hepatitis C as a part of his initial work up upon incarceration, and the same inmate was found to be positive for HCV after our testing; concluding, there was no increase in the number of affected inmates.

Conclusion:

This research was beneficial in educating the inmates of Anguilla about hepatitis

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Incidence and Predictors of Tuberculosis among Adult People Living with HIV/AIDS

by Barbarawoods1 day ago

Introduction:

Tuberculosis is the leading cause of morbidity and mortality among HIV-infected individuals. Tuberculosis and human immune deficiency virus infections are two major public health problems in many parts of the world. Globally tuberculosis is a leading cause of death among people living with HIV and it is the most potent risk factor for the development of tuberculosis. There for the aim of this study assess incidence and predictors of tuberculosis among adult people living with HIV in Afar health facilities, Northeast Ethiopia.

Conclusion and recommendation:

TB incidence rate is high among adults living with HIV. TB was high in the first year of follow up. Past history TB, not receiving IPT, low BMI, low Hgb and unable to work were the most significant predictors for occurrence of TB. Therefore the result of the study recommends for an improved TB/HIV collaboration

activity and scale up of IPT in the setup to reduce risk of TB.

 

Edelweiss Journal of AIDS welcome subm

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Neuro Effects of Opioids on the Human Brain

by Barbarawoods3 days ago

Previous researchers have explored the effect of opioids on the brain. Its adverse effects include respiratory depression, nausea, sedation, dysphoria, and impaired cognition. Opioids also modulate emotions, stress, rewards, emotions, memory, and learning (Feng et al., 2012). The euphoria and pain-relieving properties of opioids have been discussed since the Sumerian times. Research trace the mechanism of action of opioids to the coupling of receptors and inhibitors like the G-protein. The couple is activated by an agonist such an exogenous, or an endogenous μ-opioid peptide endorphin, the Gα, and Gβγ dissociate and act on effector pathways (van Rijn, DeFriel & Whistler, 2013). Pharmacological research found that pertussis-toxin-sensitive G proteins coupled with all the four types of opioids receptors. However, the most important aspect of the mode of action of the opioid receptor is its modulation of the K and Ca ions channels (Kaye et al., 2018). The effect of opioids is mediated by

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Science Can Still Captivate Us All

by Barbarawoods7 days ago

The BBC broadcaster and highly esteemed David Attenborough has repeatedly expressed that “I don’t know any child that’s not fascinated with the natural world”, a comment practically invariably followed by his believe that such fascination sadly wanes out as we grow up. I partially disagree in that it is not only children who are fascinated by the natural world. In fact, David’s documentaries about the natural world are yet to stop captivating audiences of all ages.

 

To highlight my – only partial - disagreement I will share with you a little of my own experiences in this respect. For example at social gatherings, dinner parties and the likes, when the persons next to me ask me “what do you do?” and I boringly respond that I’m a molecular biologist - if they do not immediately rush to the toilet to never coming back – there is a short silence followed by the “one-needs-to-be-a-genius-to-do-science” comment. Yet, after a while, and/or a few drinks, I find that most grownups are still

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Neuro Effects of Opioids on the Human Brain

by Barbarawoods15 days ago

This paper is an examination of the neuro effects of opioids on the human brain. The research examines the brain receptors, region, enzymes, agonists involved, and the results of its interaction with opioids. Examination of the pharmacological effect on receptors located in the neural cell membranes shows that the most important aspect is the modulation of the K and Ca ions channels. This is mediated by the activation of the delta, kappa and mu opioid receptors in the peripheral and central nervous systems. The study found that opioid receptors are coupled by guanine nucleotide binding proteins (G-proteins) to the K+ channel and voltage sensitive Ca++ channel, particularly, the N-type channel. The channels are inhibited if K+ outwards release is increased leading to short polarization time. The outward movement occurs in several regions of the spinal cords, brain, and the myenteric plexus. The rapid K+ outward movement is associated with the observed hyperpolarization and inhibition c4

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Hantzsch Reaction as a Method for Spectrofluorimetric Analysis of Penicillin G

by Barbarawoods22 days ago

A sensitive, selective, and validated spectrofluorimetric method is being described for the determination of penicillin G. The method utilizes this drug (as a source of the amine moiety) to react with acetylacetone and formaldehyde through the Hantzsch reaction. The faint yellow product of dihydropyridine derivatives was measured at an emission wavelength of 481 nm (after excitation at 416 nm). Linear calibration graphs were obtained in the range of 0.2-200 μg/mL. The experimental limits of detection and quantitation were 0.170 and 0.515 μ/mL, respectively

 

Biochemistry Modern Applications welcome submissions related to above fields. Authors may submit their valuable work at: biochemistry@ewpsjournals.com

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Neuro Effects of Opioids on the Human Brain

by Barbarawoods1 month ago

This paper is an examination of the neuro effects of opioids on the human brain. The research examines the brain receptors, region, enzymes, agonists involved, and the results of its interaction with opioids. Examination of the pharmacological effect on receptors located in the neural cell membranes shows that the most important aspect is the modulation of the K and Ca ions channels. This is mediated by the activation of the delta, kappa and mu opioid receptors in the peripheral and central nervous systems. The study found that opioid receptors are coupled by guanine nucleotide binding proteins (G-proteins) to the K+ channel and voltage sensitive Ca++ channel, particularly, the N type channel. The channels are inhibited if K+ outwards release is increased leading to short polarization time.

                        

Biochemistry Modern Applications welcome submissions related to above fields. Authors may submit their valuable work at: biochemistry@ewpsjournals.com

 

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Hantzsch Reaction as a Method for Spectrofluorimetric Analysis of Penicillin G

by Barbarawoods1 month ago

A sensitive, selective, and validated spectrofluorimetric method is being described

for the determination of penicillin G. The method utilizes this drug (as a source of the

amine moiety) to react with acetylacetone and formaldehyde through the Hantzsch

reaction. The faint yellow product of dihydropyridine derivatives was measured at an

emission wavelength of 481 nm (after excitation at 416 nm). Linear calibration graphs

were obtained in the range of 0.2-200 μg/mL. The experimental limits of detection and

quantitation were 0.170 and 0.515 μ/mL, respectively. The relative standard deviation

(n=5) at the 100 μg/mL level were 6.11 for intra-day precision and 9.42 for inter-day

precision. The method was successfully applied in the analysis of pharmaceutical

formulation; the recovery was quantitative, and the result obtained agreed with those

obtained by another reported method.

Biochemistry and  Modern Applications is an open access journal maintaining high standards of scientif

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